eng Ansari Education and Research Society Journal of Ultra Scientist of Physical Sciences August 2008 20 2 309 314 jusps-B 1304 article Jyoti Sharma 1 Mohammad Amir 2 Sabir Hussain 1 Department of Chemistry, R.R. College, Alwar, Rajasthan (INDIA) Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi - 110062 (INDIA) <p style="text-align: justify;">4-amino-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol have been prepared by treating isonicotinic acid hydrazide (1NH) successively with alcoholic KOH, CS₂ and hydrazinehydrate. These triazole derivatives were employed in the synthesis of 4-[substituted phenyl methylidene amino]-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol (1a-o) and N-[substituted phenyl]-3-pyridin-4-yl [1,2,4] triazolo [3,4-b] [1,3,4] thiadiazol-6-amine (2a-c). Some of they were found to be potential antimicrobial agents.<br /> Graphical Abstract : A series of 4-[substituted phenyl methylidene amino]-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol and N-[substituted phenyl]-3-pyridin-4-yl[1,2,4] triazolo[3,4-b][1,3,4-]thiadiazol-6-amine derivatives of quinolin-8-ol have been synthesized and evaluated for their antimicrobial activities.<br /> &nbsp;</p> https://ultraphysicalsciences.org/paper/1304/ 1,2,4-triazole amine derivatives antibacterial antifungal