eng Ansari Education and Research Society Journal of Ultra Scientist of Physical Sciences December 2010 22 3 661 674 juc 943 article J. Tomovska 1 Z. Stojanoski 2 N. Tomovska 3 University, St. Clement Ohridski, Faculty of Bio-technical Science- Bitola University, St. Ciril i Metodij, Medical Faculty, Clinical of haematology-Skopje University, St. Cytil and Metodij, Institute of Chemistry- Skopje <p style="text-align: justify;">Milk proteins act against different enzymes degenerated in peptides with different composition. Milk peptides beside opioid-like activities, also have possessive angiotenzin converting enzymatic (ACE) inhibitory activity since impeach with mineral, antithrombotic properties, antimicrobial and immune modulator activity. ACE inhibitory peptides removed from milk proteins, as IPP (izoleucin prolin prolin) and VPP (vazoleucin prolin prolin), are significance from that present ACE inhibitory in drugs. For example IC₅₀ (Inhibitory Concentration 50%) at kaptopril is on nine mol range, until value of IC₅₀ from IPP and VPP is on thousand times enhanced. Structures in artificial ACE inhibitory drugs (lizinopril, kaptopril and enalapril) have more similarity with structure of C- terminal part per peptide removed by proteins in milk.&nbsp; Major factor per ACE inhibitory activity is their small molecule mass at ACE inhibitory peptides. Mention also that advanced proceeding for used in<em> vitro</em> ACE inhibitory capable on peptides there is not default. Amount ACE used in proceeding as type at ACE substrate are important in calculation of IC₅₀ value (concentration at peptides requirement decrease at ACE activity 50%). Method used substrate N-[3-(2-furil)-acrylic]-L-fenilalanil-glicil-glicin (FAPGG) obtained from company Sigma No 7131.Determination are based on various absorbances on furanakriloil stooped three peptide FAPGG and products of enzyme accelerate hydrolyzes FAP at wave length 340 nm. Gly-Gly do not absorb light at this condition. Because products of hydrolyses FAP absorption per less at 340 nm results vary and absorbance is negative. Cardiovascular system effect of peptides derived from milk proteins are not very significant but with other components in milk has shown that they have opportunistic effect on blood pressure. Results for determination of ACE inhibitory activity of peptides in 40 samples on patients who received fermented milk products are given in the paper. There is little number to verify reality role of antihypertensive peptides upon decrease in blood pressure but is good indicator to have influence and people&#39;s health problems solution with consummate respective nutrition. In this study examination the amount of Ace inhibitory peptides on fermented products, is significant on arterial blood pressure.</p> <p style="text-align: justify;">&nbsp;</p> https://ultraphysicalsciences.org/paper/943/ ACE inhibitory peptides bioactivity peptides arterial blood antihypertensive activity artificial ACE inhibitory drugs.