Papers

Anticonvulsants may be defined as agents that prevent or diminish severity of convulsive seizures. The anticonvulsnats principal therapeutic application is in the treatment of the different varieties of epilepsy. Substituted Barbiturates posses anti convulsant activity. Series of Amides and Imids has also been found to be anticonvulsants. Quinazolinones when prepared and tested pharmacologically possessed anti convulsant activity.

In addition to above compounds, a few other compounds have been prepared and found active against convulsive seizures. Imidazoles, Imidazolidinones and Imidazolones showed moderate activity in control of epileptic seizures. Oxadiazoles, thiazoles, thiadiazole derivatives were prepared and tested for their effectiveness. Various N3 substituted hydantoin and their sodium salts were reported to possess anticonvulsant activity.

Analgesics are the drugs which subside pain partially or completely without the loss of consiousness. Morphine which was isolated from opmum was the oldest alkaloid used as pain relieving substance.

Thus 2-aminothiazole when treated with chloro acetyl chloride to get chloroacetyl derivative which on treatment with an alkalimetalcyanate in pressure of phase transfer catalyst gave N3- (thiazol-2-yl)-hydantoin, the product is then treated with chloroacetyl chlodride to get N’-(chloro-acetyl)-,N’-(3-chloropropinonyl)- and N’- (4-chlorobutryl)-N3- (thiazol-2-yl)-hydantoins. The disubstituted hydantoin were finally condensed with various amines to get various derivatives of disubstituted hydantoins which may found to possess anticonvulsant and analgesic activity.