Mathematical model for release kinetics of pulsatile drug delivery

Author & Affiliation:
POOJA ARORA
Department of Mathematics, Invertis Group of Institutions, NH 24, Near Transport Nagar, PO, Raju Bareilly 243123 UP (INDIA)
P.N. TANDON
Formerly with H.B.T.I., Kanpur India and University, Brunei Darussalam )
Keyword:
Mathematical model, release kinetics , pulsatile drug delivery
Issue Date:
December 2009
Abstract:

Controlled drug delivery systems have acquired a central stage in pharmaceutical research and development business. Through such systems spatial and or temporal releases of drugs are given to an organ in the body. In order to prevent peak-valley fluctuations, reduction in dose amount ,redosage frequency with patient comfort witout side effects. Certain pathological states demand release of drug release after a time lag instead of being released immediately. A second order kinetics model is presented for the pulsatile drug delivery kinetics to obtain a time lag between the administration of the drug and the release of the drug. This model is able to predict drug release kinetics and the fractional drug release at any time t and a high degree of positive correlation is obtained between the findings of this model and the experimental results.

Pages:
683-690
ISSN:
2319-8052 (Online) - 2231-3478 (Print)
Source:
DOI:
jusps-B
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Copy the following to cite this article:

P. Arora; P. Tandon, "Mathematical model for release kinetics of pulsatile drug delivery", Journal of Ultra Scientist of Physical Sciences, Volume 21, Issue 3, Page Number 683-690, 2018

Copy the following to cite this URL:

P. Arora; P. Tandon, "Mathematical model for release kinetics of pulsatile drug delivery", Journal of Ultra Scientist of Physical Sciences, Volume 21, Issue 3, Page Number 683-690, 2018

Available from: http://ultraphysicalsciences.org/paper/1184/

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