Mizolastine is an antihistamine drug. Two simple, sensitive and accurate spectrophotometric methods have been developed for the determination of Mizolastine in pure state and in its pharmaceutical formulations. The developed Method A is based on the reaction between drug and 1, 10-phenanthroline with ferric chloride and ortho phosphoric acid to form a colored chromogen and it shows maximum absorption at l _max 510 nm and Linearity in the range of 100-500 µg/mL. Method B is based on oxidation of the drug in the presence of ferric chloride followed by complex formation with bathophenanthroline. The developed chromogen in Method B shows maximum absorption at l _max 615 nm; Linearity in the range of 50-250 µg/mL. The results obtained were statistically evaluated and were found to be accurate and reproducible.