There are no experimental reports on anti-inflammatory activities of Eichornia crassipes in literature. In this article, we report for the first time, the efficiency of Eichornia crassipes extract in the treatment against inflammation. The methanolic extract of Eichornia crassipes leaves were investigated for the evaluation of their anti-inflammatory potential on carrageenan-induced paw oedema in Wister rats. Leaf extract of Eichornia crassipes in dose 200mg/kg (P < 0.05) and 500mg/kg (P < 0.01) on orally administration gave significant reduction of rat paw oedema at all assessment times. The Eichornia crassipes leaf extract showed maximum inhibition of 52.54% at the dose of 500mg/kg after 4 hrs. Where as the standard drug showed 62.38% of inhibition. These observations revealed that Eichornia crassipes has significant anti-inflammatory property.